DP is currently certifying support for W2012 R2 for the Cell Manager, and Installation server. Also, for Disk Agent and Media Agent. This means, for File System backups
Support is NOT offered for the User Interface (GUI) to run on W2012 R2
The Applications Integrations have to be looked at on an individual basis, for example Oracle 11 is not supported as a supported Application Integration for W2012, but, Oracle 12 does support integration with W2012 and W2012 R2
The Platform and Integration Support matrix is available at
http://support.openview.hp.com/selfsolve/document/KM00711729