I think the below picture depicts your setup.
{attached}
Hope You have added the virtual server(cluster machine) and both hosts to your cell manager as DP client.
Now if you browse virtual server, you can select file servers and shared disks to backup.
If you select the nodes, you can see associated disk file systems of nodes.
You can select from virtual server, node1 or node2. Or selecting all.
Backup will go through any network irrespective of FC/TCP.
You can configure backup in any order. I suggest you to add all as clients and configure a single backup, browsing the file systems of each node.
Do a test run before you use in production.