I don't think I have ever seen this error before, but, I think the solution is in front of you
You can supply the location by setting OB2NTDEFUSERPATH.
Specify full path or set it to empty to disable this warning.
On the machine that is producing the error, this "OB2NTDEFUSERPATH" is an environment variable, and should be added to the file
Program Data -> Omniback -> omnirc Windows 2008
or
Program Files -> Omniback -> omnirc Windows 2003
This file does not exist by default, if you don't have it, you can start with a blank Notepad, and add the line
OB2NTDEFUSERPATH=D:\Users\Default User
If the Profile is located somewhere different, alter the line accordingly. Save the file as
Program Data -> Omniback -> omnirc Windows 2008
or
Program Files -> Omniback -> omnirc Windows 2003
Make sure that the filename has no extension, like 'txt' or 'tmpl '. On this machine, stop the Data Protector INET Service, and restart it to make teh change take effect