If you start fresh you usually don't need to set up anything special in global-configFile.
As you grow you may want to tweak the Maintenance-Times (DailyCheckTime, DailyMaintenanceTime), the number of allowed Connections (MaxCrsConnections) or the number of kept SessionMessages (SmMaxAgentMessages, SmMaxMessagesPerSession).
Especially with bigger Application-Instances the various Timeouts might need a bit of extension. Noteworthy are SmWaitForFirstBackupClientSec and SmWaitForFirstRestoreClientSec if you have long Prepare-Phases f.E. in VMware. SmMaxAgentStartupRetries and SmPeerID can be adjusted when your CellServer takes longer to handle the Requests.
I only have two special ones to recommend that are usually ignored:
SetInitialMediumProtection=1 helps especially with FileLibraries that are used for staging. A new Job could clear out a "unused" FileDepot that another session just started to write to if not set.
RecoveryIndexDir=<path> is a double ensureance you have everything you need to recover a faulted CellManager.
