Hello,
You may try it but it it may be unhelpfull.
Even if you are taking a daily full backup of 1 TB the dedupe make 100 GB written to disk. If you are going to an incremental backup ... you may end to the same 100 GB written to disk (it's not the volume of backed up datas that is important but the volume of written to disk datas ...) however you can try it :-)
I've a question ... you want to replicate your datas to your DR site right ?
But how do you intend to restore some data if you activate your DR plan ?