Backup failed with 'Connection timed out' error

Hello All,

We have encounted a backup failure in monthly full backup for filesystem.  The messages section has the below critical message:

[Critical] From: XXX-XXX-XXX-XXX"/"  Time: 9/3/2013 10:44:12 AM
 Cannot connect to Media Agent on system SMA-EVA, port 1265 (IPC Cannot Connect
 System error: [110] Connection timed out
) => aborting.

Any help would be highly appreciated.