On the 4210, is the NAS share permissions "CIFS authentication is managed through AD" ? If so, check permissions via running MMC, then add snapin, click "shared folders", ADD, then next window click "another computer" and enter D2D hostname/IP. Then click ok. Shared folders for the D2D should appear under "Console root" in the left hand pane. Click shares and sharename to get properties. Check share permissions there....
some screenshots would be good to assist.
also what DP inet is running as plus what ownerships you have on the backup spec....
Can you browse the NAS source shares from the DP GUI source tab of the backup spec?